Programme

12:00–13:00 — Welcome reception

Arrival and snacks

13:00–14:30 — Session 1: Structure, Entry and Egress

Chairs: Beate Sodeik and Mirko Trilling

13:00–13:30	Keynote - Virus-mediated protein dephosphorylation in HSV-1 assembly and spread Stephen Graham, University of Cambridge
13:30–13:45	Functional Inhibition of the Human Cytomegalovirus Immunoevasin pUL11 Leonard A. Skremm, Hannover, Germany
13:45–14:00	The role of the HCMV glycoprotein B furin cleavage site in viral infectivity Inès Wullkopf, Hamburg, Germany
14:00–14:15	Portal-centric assembly of a Herpesvirus demonstrated in situ Yuliia Mironova, Hamburg, Germany
14:15–14:30	A Hydrophobic Pocket on HCMV Tegument Protein pUL94 Is Required for Initiation of Secondary Envelopment Jens von Einem, Ulm, Germany

15:00–16:30 — Session 2: Omics

Chairs: Emanuel Wyler and Manja Czech-Sioli

15:00–15:30	Keynote - 2500 Years of Betaherpesvirus Evolution... and Beyond Charlotte Houldcroft, University of Cambridge
15:30–15:45	Extended poly(A) tails are a shared feature of herpesvirus mRNAs Erik Fuhrmann, Hannover, Germany
15:45–16:00	Analysis of the Metabolome of Varicella Zoster Virus-infected Cells Reveals One-Carbon Metabolism As a Crucial Pathway for Alphaherpesvirus Infection Josephine Schenk, Hannover, Germany
16:00–16:15	Functional Epigenomics of Gammaherpesvirus Latency Marie Vollmost, Hamburg, Germany
16:15–16:30	Epigenetic Reprogramming in HSV-1 Infection: Insights from Single-Cell Multiome Sequencing Eva Neugebauer, Freiburg, Germany

17:00–17:30 — Flash Talk Session

10 × 2 min flash talks

Chairs: Cora Stegmann and Luka Cicin-Sain

1. Henriette Ebel — Structural insights into the Herpes Simplex Virus 1 (HSV-1) fusion mechanism
2. Jendrik Müller — Lack of Neuropilin-1 Prevents Murine Cytomegalovirus Infection of Murine Trophoblast Cells
3. Elena Serbe — Revertants of the thymidine kinase gene ORF36 in genome-minimized VZV-Oka variants show increased replication
4. Ronja Friedhoff — A Comparative Analysis of Latent Human Gammaherpesvirus Chromatin Dynamics
5. Florine Pitti — Identifying intrinsic mechanisms associated with GSC resistance to oncolytic HSV
6. Sampurna Chakrabarti — HSV-1 modulation of sensory neuron function
7. Greta Meyer — HCMV vaccine candidate identification: ULBP2-expressing HCMV mutants optimize NK cell function and activation
8. Marco Olguín-Nava — Death is just the next great adventure: IFN modulation of Stress-Induced Fate
9. Lucas Mendes-Monteiro — Varicella-zoster virus glycoprotein C binds IFNγ to potentiate IFNγ receptor signaling
10. Thalea Buchta — A symphony of innate immunity: The four isoforms of the zinc finger antiviral protein act in concert to restrict human cytomegalovirus replication and modulate viral gene expression

17:30–19:30 — Poster Session

19:30–22:00 — Joint dinner at Leonardo Hotel Hannover

09:00–10:30 — Session 3: Clinical virology and pathogenesis

Chairs: Felix Stahl and Sampurna Chakrabarti

09:00–09:30	Keynote - Herpesviruses: a bridge between clinical and fundamental virology Ann Vossen, Leiden MC
09:30–09:45	TSLP, SPINK5, and CYP24A1 variants are linked to the risk of eczema herpeticum in individuals with atopic dermatitis and shifts in target gene expression in the skin Katinka Döhner, Hannover, Germany
09:45–10:00	Inhibiting the Replication of KSHV, EBV, BKPyV and Adenovirus with a Novel Broadly Acting Small Molecule Targeting the Pyrimidine Synthesis Pathway Qingzhe Wang, Hannover, Germany
10:00–10:15	ResistanceProfiler (ResPro): A Framework for Standardized Herpesvirus Resistance Genotyping Jonas Fuchs, Freiburg, Germany
10:15–10:30	A T Cell Reporter System allows the quantification of NKG2D costimulatory signaling and its modulation by ULBP2-expressing HCMV vaccine candidates Irina Bevzenko, Hannover, Germany

11:00–12:30 — Session 4: Animal herpesviruses & model systems

Chairs: Barbara Klupp and Jens von Einem

11:00–11:30	Keynote - Closing the gates in two steps: How pseudorabies virus suppresses gap junction intercellular communication Herman W Favoreel, Ghent University
11:30–11:45	Human Hair-Bearing Skin Organoids reveal Cell Type Specific Susceptibility and Innate Immune Responses to Herpes Simplex Virus 1 Manja Czech-Sioli, Hamburg, Germany
11:45–12:00	Spatial and quantitative proteomics of rodent cytomegalovirus particles Rebecca Brambilla, Berlin, Germany
12:00–12:15	Murine Cytomegalovirus m119-118 encodes a new viral Fcγ receptor Laura Staliunaite, Hamburg, Germany
12:15–12:30	Cross-species analysis of human DUX4-like regulation to alphaherpesvirus infection in human, rhesus macaque, bovine, equine and porcine cells Mirko Schmitz, Freiburg, Germany

14:00–15:30 — Session 5: Immunity

Chairs: Philipp Kolb and Katja Hoffmann

14:00–14:30	Keynote - Cell-intrinsic and innate immune responses against HSV-1 infections Søren Riis Paludan, Aarhus University
14:30–14:45	A peptide derived from an HCMV encoded glycoprotein presented on HLA-C*05:01 can engage the activating killer-cell immunoglobulin-like receptor KIR2DS1 Nicola Koch, Freiburg, Germany
14:45–15:00	The RL11 family glycoprotein pUL11 Impairs NK Cell Antiviral Activity in HCMV Infection Ganbat Gantulga, Hannover, Germany
15:00–15:15	High-dimensional Profiling of Myeloid Cells in Early-Life Murine Cytomegalovirus Infection Lama Al Jurdi, Hamburg, Germany
15:15–15:30	Latent MCMV infection elicits protective tissue-associated T cell immunity against SARS-CoV-2 Luka Cicin-Sain, Braunschweig, Germany

16:00–17:30 — Session 6: Virus-host interactions

Chairs: Timothy Soh and Cristiana Cismaru

16:00–16:30	Keynote - ContRL of CMV Khanh Le-Trilling, Universitätsklinikum Essen
16:30–16:45	Investigation of Herpes Simplex Virus Type 1 (HSV-1) replication dynamics in human primary keratinocytes at different stages of epidermal differentiation Geonhee Kim, London, United Kingdom
16:45–17:00	Establishment of a model for HHV-6A latency and reactivation Dilan Serdar, Berlin, Germany
17:00–17:15	Human cytomegalovirus prevents SMC5/6 localization on viral episomes through SLF2 degradation Francesco Montagner, Ulm, Germany
17:15–17:30	Investigating the interplay between PKR antagonists during HSV-1 infection Lauren Kerfoot, Surrey, United Kingdom

18:00–22:00 — Farewell Dinner

Agorino, Berckhusenstraße 31, 30625 Hannover-Buchholz-Kleefeld (Registration required)